GDF2 Protein (AA 320-429)
Quick Overview for GDF2 Protein (AA 320-429) (ABIN6973076)
Target
See all GDF2 ProteinsProtein Type
Biological Activity
Origin
Source
Purity
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Protein Characteristics
- AA 320-429
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Characteristics
- Human GDF-2 Protein, Tag Free
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Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
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Growth Differentiation Factor 2 (GDF2) (AA 320-429) protein (His-IF2DI Tag)
GDF2 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Growth Differentiation Factor 2 (GDF2) (AA 1-429) protein (GST tag)GDF2 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- ACN, TFA in Water
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Storage
- -20 °C
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- GDF2 (Growth Differentiation Factor 2 (GDF2))
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Alternative Name
- GDF-2
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Background
- Human Growth and differentiation factor 2 (GDF-2), also known as Bone morphogenetic protein 9 (BMP-9), is a member of the BMP subgroup of the TGF-beta superfamily proteins that signal through heterodimeric complexes composed of type I and type II BMP receptors. GDF-2 Potent circulating inhibitor of angiogenesis. Signals through the type I activin receptor ACVRL1 but not other Alks. Signaling through SMAD1 in endothelial cells requires TGF-beta coreceptor endoglin/ENG. ALK1 is a signalling receptor for bone morphogenetic protein-9 (BMP-9) in endothelial cells (ECs). BMP-9 bound with high affinity to ALK1 and endoglin, and weakly to the type-I receptor ALK2 and to the BMP type-II receptor (BMPR-II) and activin type-II receptor (ActR-II) in transfected COS cells. Binding of BMP-9 to ALK2 was greatly facilitated when BMPR-II or ActR-II were co-expressed.
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Molecular Weight
- 12.1 kDa
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Pathways
- Transition Metal Ion Homeostasis
Target
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